As the title says.
See: https://www.vbulletin.com/forum/entr...itespeed-Cache
http://blog.litespeedtech.com/2011/0...uilt-in-cache/
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I don't see a reason why not. But I'm not 100%, as Varnish (at least in the linked blog) seems to require Apache which we don't use, and it sounds like you need a pricey 2-CPU license for Litespeed cache. If it works with vBSEO though, you should be able to get it working with VaultWiki.