Both add-ons appear to just set a cookie or a header, and they do so in a globally available hook location. I see no reason why the cookie would not be maintained in VW, unless perhaps you are operating the wiki on a separate domain.
On the other hand, vBulletin no longer offers or supports the add-on you refer to, so it is neither possible nor a good idea to extend the add-on in any way if that were necessary.
From what I can see, these add-ons should not conflict with VW4 at all, and I see no reason why guest caching would not work on wiki content pages if it already works on regular forum pages.